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작성일 : 17-02-23 13:26
Direct detection of cysteine using BaTiO3 self-powered biosensor, Biosensors and Bioelectronics
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   2017_Sophia_BiosensorandBioelectronics_Published.pdf (1.2M) [3] DATE : 2017-02-23 13:26:17
Biosensors and Bioelectronics 91 (2017) 203–210

  Direct detection of cysteine using functionalized BaTiO3 nanoparticles film based self-powered biosensor

  Sophia Selvarajana, Nagamalleswara Rao Allurib, Arunkumar Chandrasekharc, Sang-Jae Kima,c,⁎,1

  Simple, novel, and direct detection of clinically important biomolecules have continuous demand among
scientific community as well as in market. Here, we report the first direct detection and facile fabrication of a
cysteine-responsive, film-based, self-powered device. NH2 functionalized BaTiO3 nanoparticles (BT-NH2 NPs)
suspended in a three-dimensional matrix of an agarose (Ag) film, were used for cysteine detection. BaTiO3
nanoparticles (BT NPs) semiconducting as well as piezoelectric properties were harnessed in this study. The
changes in surface charge properties of the film with respect to cysteine concentrations were determined using a
current–voltage (I-V) technique. The current response increased with cysteine concentration (linear concentration
range=10 μM–1mM). Based on the properties of the composite (BT/Ag), we created a self-powered
cysteine sensor in which the output voltage from a piezoelectric nanogenerator was used to drive the sensor. The
potential drop across the sensor was measured as a function of cysteine concentrations. Real-time analysis of
sensor performance was carried out on urine samples by non-invasive method. This novel sensor demonstrated
good selectivity, linear concentration range and detection limit of 10 μM; acceptable for routine analysis.