20171201 Sophia Selvarajan, Nagamalleswara Rao Alluri, Arunkumar Chandrasekhar, Sang-Jae Kim, Unconventional active biosensor made of piezoelectric BaTiO3 nanoparticles for biomolecule detection, Sensors & Actuators: B. Chemical, Volume 253, December 2017, Pages 1180-1187
A smart biosensor based on piezoelectric and semiconducting properties of Barium titanate nanoparti-cles (BT NPs) by means of a piezoelectric nanogenerator (PNG) is reported for the first time. An Al/BT/ITONG (Aluminum (Al)/Barium titanate (BT)/Indium Tin Oxide (ITO) nanogenerator) was devised as a self-powered biosensor for actively detecting glucose. The piezoelectric output generated from this NG hasdual functions, as both an energy source and a biosensing signal. The biomolecule alters device conduc-tance (charge-carrier density), providing a gate potential, and can vary the local work function and bandalignment due to its adsorption on the surface of BT NPs (interfacial contact effect). Here, we tailored thepiezoelectric and semiconducting properties of BT NPs using glucose molecules. The glucose molecules(lewis base) on the surface of BT NPs film (lewis acid) act as a gate potential, and the field effect even-tually influence the charge carrier density (electrons) of BT NPs film, which varies the screening effectof free-carriers on the piezoelectric output. The novel self-powered glucose biosensor has good selec-tivity (∼6-fold increase in response vs. interferents) and the approach demonstrated here can serve asa prototype for the development of next-generation smart/self-powered nanosystems for theranosticapplications.